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DeCS
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Descriptor English:
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MAP Kinase Signaling System
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Descriptor Spanish:
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Sistema de Señalización de Quinasas PAM
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Descriptor Portuguese:
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Sistema de Sinalização das MAP Quinases
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Synonyms English:
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MAP Kinase Cascade
MAP Kinase Signaling Pathways
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Tree Number:
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G04.335.880.560
G06.184.850.560
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Definition English:
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An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade. |
See Related English:
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MAP Kinase Kinase Kinases
Mitogen-Activated Protein Kinase Kinases
Mitogen-Activated Protein Kinases
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History Note English:
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2000
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Allowable Qualifiers English:
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Record Number:
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34468
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Unique Identifier:
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D020935
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Occurrence in VHL:
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Similar:
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DeCS SciELO LILACS LIS
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